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Gene expression and response to psychological therapy

gse94119

Description

This study represents the first investigation of genome-wide expression profiles with respect to psychological treatment outcome. Participants (n=102) with panic disorder or specific phobia received exposure-based CBT. Treatment outcome was defined as percentage reduction from baseline in clinician-rated severity of their primary anxiety diagnosis at post-treatment and six month follow-up. Gene expression was determined from whole blood samples at 3 time-points using the Illumina HT-12v4 BeadChip microarray. No changes in gene expression were significantly associated with treatment outcomes when correcting for multiple testing (q<0.05), although a small number of genes showed a suggestive association with treatment outcome (q<0.5, n=20). Study reports suggestive evidence for the role of a small number of genes in treatment outcome. Although preliminary, the findings contribute to a growing body of research suggesting that response to psychological therapies may be associated with changes at a biological level.

Overall Design

Whole blood RNA was collected from patients (n=102) receiving exposure-based CBT at pre- and post-treatment and at follow-up, for investigation of association with therapy outcome. Includes 9 technical replicates.

Histogram

Data and Resources

Raw Files [315]

Additional Info

Field Value
Source https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE94119
Type of Data

Expression profiling by array

Technology

Microarray

GSE Submission Date 26/01/2017
GSE Authors Susanna,,Roberts; Kathryn,J,Lester; Thalia,C,Eley
Dataset Last Updated December 1, 2020, 18:53 (UTC)
Dataset Created December 1, 2020, 17:09 (UTC)