Dataset

Early growth response protein-1 coordinates lipotoxicity-associated placental inflammation: Role in Maternal Obesity

gse43685

Description

Maternal obesity during pregnancy leads to a pro-inflammatory milieu in the placenta. We conducted a global transcriptomic profiling in BeWo cells following palmitic acid (PA, 500 uM) and/or TNF-alpha (10 ng/ml) treatment for 24 h. Microarray analysis revealed that placental cytotrophoblasts increased expression of genes related to inflammation, stress response and immediate-early factors in response to plamitic acid, TNF-alpha or a combination of both. Our results suggest that fatty acids and inflammatory cytokines induce inflammation in placental cells via activation of JNK-Egr-1 signaling.

Overall Design

global transcriptomic profiling in BeWo cells following palmitic acid (PA, 500 uM) and/or TNF-alpha (10 ng/ml) treatment for 24 h

Histogram

Data and Resources

Raw Files

Raw Files [8]

gsm1068188
Control-1
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gsm1068189
Control-2
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gsm1068190
TNF-1
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gsm1068191
TNF-2
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gsm1068192
PA-1
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Additional Info

Field	Value
Source	https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE43685
Type of Data	Expression profiling by array
Technology	Microarray
GSE Submission Date	23/01/2013
GSE Authors	Jessica,,Saben; Ying Zhong; Horacio Gomez-Acevedo; Keshari,M,Thakali; Sarah,J,Borengasser; Aline Andres; Kartik Shankar
Dataset Last Updated	December 1, 2020, 21:33 (UTC)
Dataset Created	December 1, 2020, 17:09 (UTC)